Tıpta Yenilikçi Yaklaşımlar Dergisi
Abbreviation: JIAM | ISSN (Online): 2757-7589 | DOI: 10.29329/jiam

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Tıpta Yenilikçi Yaklaşımlar Dergisi 2020, Cil. 1(1) 46-62

Okratoksin A'nın Fiziksel, Kimyasal Özellikleri ve Sinyal Yolakları Üzerine Etkileri

Fevziye Özdemir Şimşek & Nurten Özçelik

ss. 46 - 62   |  DOI: https://doi.org/10.29329/jiam.2020.299.5

Yayın tarihi: Ocak 05, 2021  |   Okunma Sayısı: 288  |  İndirilme Sayısı: 547

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Özet

Okratoksin A (OTA), 1965 yılında Aspergillus ochraceus suşlarının ikincil metaboliti olarak keşfedilmiştir. OTA başlıca Penicillium verrucosum, Aspergillus ochraceus ve Aspergillus carbonarius küf mantarı türleri tarafından üretilen bir mikotoksindir. Okratoksin A, renksiz, suda az ancak sulu sodyum bikarbonatlı çözeltilerde iyi çözünen, zayıf organik asit gibi davranan, kristal toz halinde bir bileşiktir. Isıya karşı oldukça dirençlidir. Işık ve havaya dayanıklı olmayıp, nemli ve güneş ışığı gibi koşullara maruz kaldığı zaman bozulabilir.

OTA’nın doğal kontaminasyon dozlarının seçici olarak böbrekleri ve böbrek fonksiyonlarını etkilediği, bunun yanı sıra karaciğer, immün sistem ve beyin hücrelerinin de OTA’nın olası hedefleri olduğu gösterilmiştir. OTA’nın böbrek, karaciğer ve beyin gibi bazı dokularda hasara yol açtığı tespit edildiği görülmektedir. Genel olarak, non-genotoksik karsinojenler sınır etki üreten maddeler olarak düşünülmektedir. Karsinojeninlerin non-genotoxic mekanizmalarından dolayı DNA üzerine direkt kimyasal bir etki içermemektedir, daha çok hedef hücreler üzerine ya da hücre dışı matriks üzerine kanserojen etkiler gösterdikleri düşünülmektedir. OTA serbest radikal oluşturarak lipit peroksidasyonuna neden olur ve toksisitesini ortaya çıkarır. OTA’nın sinyal yolakları üzerine yapılan çalışma sonucunda JNK ve p38 aktivasyonunu teşvik ettiği ortaya koyulmuştur.

Derlemede Okratoksin A’nın fiziksel ve kimyasal özellikleri, sinyal yolakları ve hedef doku-organlarda etkilerinin incelenmesi ve genel literatürün tartışılması amaçlanmıştır.

Anahtar Kelimeler: Okratoksin A; Sinyal Yolakları; Hedef Organ; Böbrek

Bu makaleye nasıl atıf yapılır

APA 6th edition
Simsek, F.O. & Ozcelik, N. (2020). Okratoksin A'nın Fiziksel, Kimyasal Özellikleri ve Sinyal Yolakları Üzerine Etkileri . Tıpta Yenilikçi Yaklaşımlar Dergisi, 1(1), 46-62. doi: 10.29329/jiam.2020.299.5

Harvard
Simsek, F. and Ozcelik, N. (2020). Okratoksin A'nın Fiziksel, Kimyasal Özellikleri ve Sinyal Yolakları Üzerine Etkileri . Tıpta Yenilikçi Yaklaşımlar Dergisi, 1(1), pp. 46-62.

Chicago 16th edition
Simsek, Fevziye Ozdemir and Nurten Ozcelik (2020). "Okratoksin A'nın Fiziksel, Kimyasal Özellikleri ve Sinyal Yolakları Üzerine Etkileri ". Tıpta Yenilikçi Yaklaşımlar Dergisi 1 (1):46-62. doi:10.29329/jiam.2020.299.5.
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